WHAT IS REGENERATIVE MEDICINE?
Regenerative Therapy Definition and Types
Regenerative medicine is a cellular-level therapy that aims to improve the function of damaged or diseased tissue or organs by introducing cells to replace damaged cells. Today, regenerative medicine is being recognized for its therapeutic potential for a wide variety of medical conditions across a range of specialties, including orthopedics, rheumatology, cardiology, neurology, immunology, and more.Because of their ability to differentiate into cells that carry out the roles needed in a variety of organs, cell allografts are an essential regenerative tool. When these allografts are introduced into a damaged tissue or organ, they have the ability to evolve and carry out necessary functions, compensating for the damaged cells. As a minimally invasive process, regenerative therapy harnesses the natural capabilities of regenerative allografts and the body’s own ability to heal, providing an opportunity to avoid invasive procedures.
Scope of Regenerative Therapy
Regenerative cell allografts, that occur naturally in the body, are “naive” or unspecialized. This means that, based on cues from their environment, these cells can transform into and assume the functions of a variety of different cells in the body. The ability to mature in a context-specific way is the key to the vast potential of cells in regenerative medicine. When injected into a damaged tissue, the cells specialize to carry out the necessary function in that particular area, improving symptoms and function.
What Makes MSC's Different
MigrationRegenerative cell allografts, that occur naturally in the body, are “naive” or unspecialized. This means that, based on cues from their environment, these cells can transform into and assume the functions of a variety of different cells in the body. The ability to mature in a context-specific way is the key to the vast potential of cells in regenerative medicine. When injected into a damaged tissue, the cells specialize to carry out the necessary function in that particular area, improving symptoms and function.
RepairIn the case of tissue damage, MSCs have the ability to release growth factors and specialize into a number of tissue cell types that allow for the tissue to be regenerated.
ImmunomodulationWhen foreign cells are introduced in the body, the concern is that they will often generate an immune response. Because MSCs express very few antigens on their surfaces that can generate an immune response (like MHCI or MHCII), they do not elicit a reaction from the patient’s immune system T-cells, making them safe to use.
Reduction of InflammationMSCs reduce the signal cells that promote inflammation (like TNF-alpha and TNF-gamma). While this is another function that helps them to avoid the immune response, it is also essential to the cells’ utility in chronic and autoimmune diseases characterized by inflammation.
where Do These Cells Come From
While regenerative cells are found throughout the body, the cells used in medicine today may be derived from four different sources: umbilical cord tissue, embryonic tissue, bone marrow, and adipose tissue. However, some sources have their drawbacks. Embryonic cells raise ethical concerns, while bone marrow and adipose tissue cells can only be retrieved through invasive surgical procedures.
Considering this, Nex cell scientific uses exclusively umbilical cord derived cells. Umbilical cord tissue retrieval, which takes place immediately after the umbilical cord is cut upon delivery, is non-invasive and ethically sound. The umbilical cord tissue is a source of growth factors that also play an important role in regenerative medicine.
Considering this, Nex cell scientific uses exclusively umbilical cord derived cells. Umbilical cord tissue retrieval, which takes place immediately after the umbilical cord is cut upon delivery, is non-invasive and ethically sound. The umbilical cord tissue is a source of growth factors that also play an important role in regenerative medicine.
How Stem Cells Work:
Respond
When an area of the body is injured or not functioning properly, distress signals are sent through the bloodstream. These signals serve to recruit cells to the affected area.
Dock
Once in the affected area, the cells dock on other cells and begin to produce signaling proteins that work to regulate inflammation, aid in angiogenesis, and promote tissue repair.
Specialize
Cells then mature to carry out the functions of the cells that are needed. In this way, they compensate for the cells that are damaged, nonfunctional, or lacking to improve organ function, and consequently improve disease symptoms.